R-Alpha Lipoic Acid with Biotin
Jarrow Formulas R-Alpha Lipoic Acid with Biotin provides superior Bioavailability and Acitivity. Jarrow Formulas Stabilized R-Alpha Lipoic Acid (Bio-enhanced Na-RALA) is R-(+)-Alpha Lipoic Acid (RALA). It is heat and shelf stable and exhibits high bioavailability. Most alpha-lipoic acid supplements include equal amounts of the (R) and (S) forms. However, only RALA is found naturally in the body. RALA is a unique cofactor in energy production and helps regulate glucose and lipid metabolism. RALA promotes the synthesis of glutathine and the induction of Phase II detoxification enzymes. d-Biotin is a natural cofactor and may compliment RALA in promoting mitochondrial health.
About R-Alpha Lipoic Acid
The precursor to lipoic acid, octanoic acid, is made via fatty acid biosynthesis in the form of octanoyl-acyl carrier protein. In eukaryotes, a second fatty acid biosynthetic pathway in mitochondria is used for this purpose. The octanoate is transferred from a thioester of acyl carrier protein to an amide of the lipoyl domain by an octanoyltransferase. The sulfur centers are inserted into the 6th and 8th carbons of octanoate via the a radical s-adenosyl methionine mechanism, by lipoyl synthase. The sulfurs are from the lipoyl synthase polypeptide. As a result, lipoic acid is synthesized on the lipoyl domain and no free lipoic acid is produced. Lipoic acid can be removed whenever proteins are degraded and by action of the enzyme lipoamidase. Free lipoate can be attached to the lipoyl domain by the enzyme lipoate protein ligase. The ligase activity of this enzyme requires ATP. Lipoate protein ligases proceed via an enzyme bound lipoyl adenylate intermediate.
About Jarrow Formulas
Jarrow Formulas, which is based in Los Angeles, California, USA, is a formulator and supplier of superior nutritional supplements. The company was founded in 1977 and incorporated in 1988. Today it markets its products in the United States, Mexico, Canada and throughout the world. The owners and officers of the company are: Jarrow L. Rogovin, President; Ben Khowong, CEO/CFO and Peilin Guo, Executive Vice President.
Jarrow Formulas' mission is reflected in its motto 'Superior Nutrition and Formulation".
Jarrow Formulas' complete line of nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Both retailers and consumers are assured of purity, value and potency when choosing these products.
The company is active in monitoring governmental regulatory affairs, which affect the nutritional industry. It also vigorously promotes the rights of Americans to free access to dietary supplements. Jarrow Formulas funds research studies on important nutritional products such as CoQ10, to ensure that customers receive the full biological value of these products.
Jarrow Formulas' Mission
Jarrow Formulas' goal is to promote optimal health with high quality, effective, affordable and "cutting edge" formulations, which are based on sound scientific research data. The company's professional staff is actively involved in clinical studies and in working with researchers from universities, institutes and other academic environments around the world. Jarrow Formulas strives to provide the best service and technical support to its customers.
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