Medical Grade Manuka Honey is distinct from food grade manuka honey; it is harvested and processed to specific published standards. Medical Grade Manuka Honey has been sterilized with heat. Because of its purity and strength, less is needed to produce a therapeutic benefit. (keep the honey in the mouth for as long as possible, then swallow - this also increases the therapeutic benefit).Manuka Honey is the only honey unaffected by light, heat, lack of oxygen, or the enzyme catalase - (found in tissue and tissue fluid). Medical Grade Manuka Honey is safe for topical use.