Doctor's Best PepZin GI is a complex of the mineral zinc and l-carnosine. PepZin GI was developed in Japan and has been in widespread use there since 1994. Research on PepZin GI has found that it is extremely beneficial in supporting healthy gastric function. PepZin GI acts by supporting the integrity of stomach cells and may exert free-radical scavenging activity, inhibiting the expression of certain cytokines. PepZin GI also promotes health mucus secretions from stomach cells while maintaining a healthy bacterial balance in the GI tract.
- Science-based nutrition
- Dietary supplement
- Promotes a healthy stomach lining & environment
- Helps relieve occasional gastric discomfort
- Maintains a healthy GI environment
- Supports the health of gastric cells
PepZin GI is an exclusive, patented complex of zinc and L-carnosine that was first developed in Japan and has been in use since 1994. This special chelated form of the mineral zinc has a unique ability to exert its effects directly on the cells of the stomach lining. When zinc is complexed to L-carnosine, it dissociates in the stomach at a slower rate. This prolonged existence allows it to maintain its gastric healing effect over a longer period of time. The proprietary chelation process along with excellent scientific research make PepZin GI your best choice for supporting gastric health.
In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-carnosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-Lcarnosine group. Of the group, 92% of the participants were rated as "moderately improved" or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.
In another study, 28 patients with gastric discomfort were given a zinc-L-carnosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be "significantly improved" was 68.4%. After eight weeks, the "significantly improved" number was 68.8%. Over 60% of these patients remained in the "significantly improved" category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-carnosine compound beyond the time it is taken.
Maintains a Healthy GI Environment
The mineral zinc in PepZin GI is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds,and maintenance of carbohydrate and lipid metabolism.
PepZin GI may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-carnosine co m pound may have effects on certain strains of harmful bacteria and, therefore, may be able to help maintain a GI environment that is favorable to health. By supporting the bacterial balance in the stomach, PepZin GI can help maintain a healthy mucosal lining.
Supports the Health of Gastric Cells
PepZin GI has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-carnosine, or a combination of zinc-L-carnosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-carnosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress.
Additional animal research further confirms the gastro-supportive effects of PepZin GI. The stomach lining of rats fed zinc-L-carnosine compound prior to being exposed to monochloramine, a known pro-oxidant (producer of free radicals), fared better than the stomach lining of rats from the control group that were exposed to monochloramine without the zinc-L-carnosine compound beforehand.
About Doctor's Best
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Every product is thoroughly researched and backed by the latest scientific studies conducted in the field. The formulations reflect the amounts of ingredients shown to be beneficial based on the results of scientific investigations. Doctor's Best uses patented, trademarked ingredients backed by scientific studies and clinical research. They never use insignificant quantities to enhance the label.
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