Phosphatidyl Serine
Doctor's Best Phosphatidyl Serine provides the essential brain nutrient phosphatidylserine in a matrix of other phospholipids and cofactors. Phosphatidylserine and other phospholipids are structural components of brain neurons that can enhance cell-to-cell communication. Studies have shown the ability of supplemental phosphatidylserine to support healthy cognitive function. It may enhance healthy memory and thinking ability by facilitating communication between neurons. Best Phosphatidylserine contains phosphatidylserine and other essential nutritional cofactors in a formula that is suitable for vegetarians.
- Suitable for vegetarians
- Science-based nutrition
- Provides building blocks for healthy neurons
- Supports healthy memory and thinking ability
Provides Building Blocks for Healthy Neurons
Phospholipid molecules are key components of cellular membranes. The incorporation of these molecules into membranes facilitates healthy cell function, toxin removal and cellular signaling. One of the most important of these compounds for neural cells is phosphatidylserine (PS), which makes up about 10% of the composition of neuronal cell membranes. Phosphatidylserine can be made by the body and is also taken into the body as part of the diet. Some researchers believe that supplemental PS may be highly indicated as we age, since our natural diets may contain suboptimal amounts of phosphatidylserine. It is thought to be especially important in maintaining the general structure and function of the neuron. Supplemental phosphatidylserine may have beneficial effects on memory function by allowing neurons in the neuron networks to effectively communicate with one another.
Studies suggest that phosphatidylserine enhances signal transmission between neural cells. An in vitro study measured the effects of phosphatidylserine on hippocampal (brain) slices taken from male albino rats. In this study, the researchers found that when the brain slices were bathed in PS, they had increased efficiency of nerve transmission and an enhancement of long-term potentiation (which is related to information storage in the brain) compared to control.
Supports the Body During Mental and Physical Stress
A number of small studies have emerged that have shown positive effects of PS supplementation on the stress response. The majority of the studies have looked at the effects on stress induced from physical exertion, although one study in 2001 looked at the effects on mental stress in 48 male university students. These students were given either 300mg of PS or placebo for 30 days. Baseline and post-supplementation measurements of mood, neuroticism and extroversion were assessed by questionnaire, and vital signs were taken. After 30 days, the students were given a standard acute stress test involving a difficult time-limited mathematical calculation, and then measurements were taken a third time. The sub-group of students who were rated more "neurotic" experienced significantly less stress and better mood under the pressure by taking PS compared to placebo.
A further crossover study of 8 healthy men looked at the effects of an acute dose of PS on hormonal responses after physical stress. The men underwent physical exercise between 8:30 and 9:30am after an overnight fast. They were each tested 3 times in a crossover fashion with a one-week interval between testing. Blood samples were taken before exercise, and were followed by an intravenous injection of either placebo, 50 mg of PS, or 75 mg of PS. Subsequent blood samples were taken during and after exercise. The secretion of both cortisol and ACTH (the pituitary hormone that regulates cortisol) were significantly blunted after exercise by supplementation with phosphatidylserine, as compared to placebo. Other hormones, including norepinephrine, epinephrine, growth hormone, and dopamine were not affected by phosphatidylserine supplementation. The author showed a similar significant response of oral PS on cortisol and ACTH after exercise stress in 9 healthy men. Subjects took 800 mg of phosphatidylserine or placebo orally for 10 days in a double-blind, randomized cross-over study.
In another investigation, eleven fit male subjects with at least 4 years of weight training experience were given 800mg of phosphatidylserine or placebo for two weeks in a cross-over study.16 During this time they were involved in eight intensive weight lifting sessions over the two weeks. Although resting cortisol levels did not differ throughout the training in the phosphatidylserine versus the placebo groups, the post-exercise level of cortisol was significantly lower in the PS group. ACTH was not affected by phosphatidylserine supplementation in this study. The PS significantly enhanced the perception of well-being and lowered ratings of muscle soreness in response to the severe over-training they underwent during the study. The severity of the training was confirmed by increases in creatine kinase (a measure of damage to the muscles) in both groups.
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