VESIsorb CoQ10 Plus Omega-3

Doctor's Best CoQ10 and the Omega-3 fatty acids DHA and EPA are vitamin-like nutrients with clinically proven benefits. This CoQsource preparation with its patented VESIsorb delivery system is the pinnacle of efficient nutrient delivery. Through its naturally self- assembling, nano-colloidal delivery system, VESIsorb amplifies the measurable blood levels of these nutrients. All three are building blocks for the cell membrane systems that generate energy and manage metabolism.

• Science-based nutrition
• Dietary supplement
• Nano-colloid bioavailability breakthrough
• Achieves superior CoQ10 and Omega-3 blood levels over other formulations
• Facilitates energy generation, antioxidant protection, cell membrane performance
• Supports wellness via the heart, brain, muscles, immune system, joints and other organs

Coenzyme Q10 ("CoQ10") and the omega-3 fatty acids DHA and EPA are vitamin-like nutrients that have numerous clinically proven benefits and functionally complement each other's actions.1,2,3 But these nutrients have limited absorption when taken by mouth. This VESIsorb combination of CoQ10, DHA and EPA is formulated to optimize the delivery of these nutrients to their exclusive site of action: the membrane systems of all the body's cells. The cell membrane system is a network of interconnecting, ribbon-like structures that enclose the contents of the cell and also subdivide its interior into functionally specialized compartments. The cell membranes are essentially energy dynamos that drive all of metabolism. CoQ10, DHA and EPA all are building blocks for these cell membranes, and complement each other to support healthy membrane dynamics.

Being oil-compatible to fit deep into membranes, the nutrients CoQ10, DHA and EPA all mix very poorly with water and this limits their absorption from the water-phase of the intestinal contents through to the bloodstream. VESIsorb is a new technology that creates an ultra-fine, oily colloidal dispersion of these nutrients in water, to dramatically improve their rate and extent of absorption into the blood.

VESIsorb, The Nano-Colloid Nutrient Delivery Breakthrough

The VESIsorb technology6 uses a patented mix of water-compatible but oily molecules to combine with the poorly water soluble CoQ10, DHA and EPA molecules and convert them into an oily molecular complex. Once this mixture is exposed to water, as occurs when they are consumed by mouth, the complex self-reorganizes into ultra-microscopic fluid colloidal droplets. These are termed nano-colloids, being typically less than 100 nanometers in diameter (1 nanometer being one millionth of one millimeter). They dissolve the actives into the aqueous phase, from which these can diffuse into close proximity with the intestinal lining cells and more readily become absorbed.

Coenzyme Q10 (CoQ10; Ubiquinone), A Conditionally Essential Nutrient

This is a vitamin-like nutrient, currently classified as "conditionally essential" for health. The body can make limited amounts of CoQ10, but additional supplies from the diet seem necessary to maintain good health. CoQ10 deficiencies are well documented, which is one reason that supplementing with CoQ10 is useful to raise its blood levels into the range that will promote optimal health.

Deficiencies of CoQ10 can result from inherited mutations, intensive physical exercise, exposures to oxidative toxins, or consumption of statins and certain other pharmaceutical drugs. The use of CoQ10 supplements with poor bioavailability often is insufficient to correct such deficiencies and has unreliable benefit from one individual to another. The VESIsorb technology is an efficient delivery system that virtually guarantees blood CoQ10 will be elevated into the range necessary for resolving deficiency.

CoQ10 Irreplaceable for Cell Energy Production

CoQ10 is literally "the spark of life" because it is indispensable for the generation of life energy as ATP (adenosine triphosphate). This energy function of CoQ10 is unique and cannot be substituted for by any other nutrient. The cell's major energy generators are its hundreds of mitochondria, each having its own functional compartment inside the cell as demarcated by double membranes. Though the entire cell membrane network carries CoQ10, the membranes of the mitochondria have by far the highest unit CoQ10 content.

Relying on CoQ10, the mitochondria generate more than 90 percent of the body's ATP. Within the core of the inner mitochondrial membrane, molecules of CoQ10 are continually moving back and forth, rapidly shuttling electrons between large protein catalysts that altogether generate ATP. DHA and EPA give to the membrane core a flexibility (semi-fluid state) that facilitates these ultra-rapid migrations of CoQ10.

Mitochondrial efficiency tends to decline with age. Mitochondrial decline typically features lowered ATP generation capacity; conversely, oral supplementation with CoQ10 to raise its blood levels above certain thresholds can have valuable benefits against occasional fatigue problems and for optimal function of the brain, heart, skeletal muscles, and other organs.

CoQ10 Provides Potent and Unique Antioxidant Protectant

CoQ10 is also a potent antioxidant, able to readily donate electrons to block "free radical" and other oxidative attack on cell membranes. As an antioxidant CoQ10 seems especially important for the mitochondrial membranes. This could be a very important contribution to health, because the very same "oxidative phosphorylation" process that generates ATP in the mitochondria also creates a continuous leakage of oxygen free radicals that can create substantial cell damage unless restrained by antioxidant defense. Many experts believe oxygen free radical damage could be the ultimate restraint on the human lifespan.

CoQ10 also helps protect the rest of the cell's labyrinthine system of membranes, even helping to conserve the vitamin E of membranes by recycling it from the oxidized to the antioxidant reduced form. There is good evidence for antioxidant synergy between CoQ10 and vitamin E. As vitamin E or total antioxidant capacity falls within the membranes, their CoQ10 content tends to rise, perhaps as a compensatory adaptation. CoQ10 seems to be centrally involved in maintaining the membrane's "redox poise", a delicate balance between oxidation and reduction that is important for good health.

CoQ10 Supports the Heart and Blood Vessels

CoQ10 provides key support for the heart in its crucial function as the body's mechanical pump, as concluded from two "meta-analyses" that separately pooled data from multiple clinical trials. CoQ10's high degree of importance for the beating heart is consistent with the heart muscle fibers having the highest density of mitochondria and the highest CoQ10 concentration of any tissue.

CoQ10 also supports the blood vessels and can boost their performance. In its role as energy catalyst CoQ10 helps sustain the endothelium, the highly active single layer of flattened cells that line the inner blood vessel walls. As an antioxidant, CoQ10 supports circulating blood factors against oxidative stresses that can render them more toxic.

CoQ10 also helps support the maintenance of healthy blood pressure, as indicated by a 2007 meta-analysis of 12 clinical trials. In all, CoQ10 nutritionally supports the heart, the blood vessels and the circulating blood via dual and complementary molecular action mechanisms.

CoQ10 Gives Crucial Support To the Brain

The brain is a tremendous ATP guzzler. At rest, this 3-pound organ uses about 20 percent of the body's total energy; when fully engaged it can consume 50 percent or more. Brain cells obtain this energy from intense mitochondrial activity. Functional brain decline as a part of normal aging typically begins with impaired production of ATP in the mitochondria. Dietary supplementation with CoQ10 has been shown to improve brain functions, and at blood CoQ10 levels that are likely attainable with the VESIsorb delivery system.

Supports Immune System Performance

The pioneering CoQ10 researcher Karl Folkers and his colleagues found that CoQ10 supplementation increased IgG antibody and CD4 T-lymphocyte ("helper cell") counts in healthy subjects. Other immune cells ("phagocytes", "killer cells") use CoQ10 for mobility and to generate free radicals directed against their prey. Some of these cells re-direct the same CoQ10 electron transfer properties normally used to make energy, into generating highly destructive free radicals. An Italian study of subjects aged over 90 found that natural killer cell performance was superior in subjects with the best CoQ10 status.

Benefits of CoQ10 as documented from clinical studies include:

• Support for the gum tissue against oxidative damage
• Improvement in the time to fatigue during aerobic exercise
• Enhanced resistance of the skeletal muscles to damage from intense exercise
• Facilitation of flow-mediated dilation function in the peripheral circulation
• Energetic and antioxidant support for healthy spermatozoa motility

It is still not clear whether tissue CoQ10 levels always decline with advancing age. But considering CoQ10's diverse array of proven benefits and its proven safety for long-term use, older individuals (or young individuals with occasional fatigue) would be well advised to take supplemental CoQ10 daily. So also would individuals who are vegetarians, those who take statin drugs (which are known to deplete CoQ10), or others taking drugs known to have oxidative effects that could deplete CoQ10 and other antioxidants.

In the early stages of CoQ10 research, poor bioavailability was the major factor limiting its efficacy as a dietary supplement. The advent of the VESIsorb delivery technology now makes delivery of CoQ10 to the tissues routine, efficient and affordable.

Omega-3 DHA and EPA

Like CoQ10, the omega-3 nutrients DHA (DocosaHexaenoic Acid) and EPA (EicosaPentaenoic Acid) are cell membrane building blocks that are both protective and crucial to the health of the cell as a whole. Like CoQ10, they operate only in cell membranes, but they are widely distributed throughout the cell membrane networks. DHA and EPA are especially important for cell membrane fluidity, which in turn supports a great variety of important cell functions.

DHA and EPA are anchored into the membrane's matrix by phospholipid molecules. Dangling from the phospholipid's head section, rather like tails, the long, electron-dense hydrocarbon chains of DHA and EPA extend deep into the membrane's core zone and help to keep it semi-fluid. For optimal membrane function it is essential to have sufficient omega-3 chains to maintain this semi-fluid state at all times. The omega-3 chains also allow freedom of movement for CoQ10 within the membrane's core.

DHA has a longer molecular chain than EPA (22 carbons versus 20 for EPA), and therefore a greater fluidizing effect on membranes. EPA also contributes to cell membrane fluidity, and is a parent source of messenger substances - prostaglandins and other "eicosanoids" - that regulate healthy function (homeostasis) throughout the tissues. Recently it was established that DHA also is a source of messengers-called "docosanoids" or more specifically protectins, resolvins and maresins. The messengers produced from EPA and DHA overlap in their actions and altogether help support a balanced immune response.

Diverse Circulation Benefits of DHA and EPA

Taken together, the thousands of epidemiologic, observational, experimental and randomized controlled trials published over the past 3 decades document clear cardiovascular benefits from fish oil containing DHA, EPA, and other long-chain omega-3 nutrients. These long-chain omega-3s promote continued cardiovascular wellness, and the shorter-chain ALA (alpha-linolenic acid) from plants does not substitute for these benefits. Humans convert less than 5% of dietary ALA to EPA (and less to DHA), therefore vegetarians are well advised to take supplemental DHA and EPA as dietary supplements.

The weight of the evidence supporting the benefits of fish oil with DHA and EPA for heart and blood vessel health is so great, that in 2003 the American Heart Association (AHA) joined with other professional healthcare organizations worldwide to issue strong recommendations that individuals consume DHA and EPA daily for cardiovascular wellbeing. In 2004, the U.S. Food and Drug Administration (FDA) announced it would "consider exercising enforcement discretion" for a qualified health claim: "Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease."

The proven cardiovascular benefits of fish oil with DHA and EPA include:

• Supporting healthy heart rate variability
• Supporting healthy blood pressure already in the normal range
• Supporting healthy arterial and endothelial function
• Favorably affecting autonomic tone (non-conscious nervous control of organ functions).

DHA and EPA can be safely consumed along with statin drugs. Since statins interfere with the body's CoQ10 synthesis, supplementing with VESIsorb CoQ10 Plus Omega-3 would offer a compound advantage to the statin user: the benefits of DHA and EPA combined with the benefits of CoQ10 and repletion of CoQ10 lost to the statin therapy.

Brain Benefits From the Omega-3s

The evidence for brain benefits from omega-3 supplementation is almost as overwhelming as the cardiovascular evidence. Among the proven benefits of omega-3s for the brain are DHA's essentiality for the pre-and post-natal development of the visual and other sensory functions, along with the brain's cognitive functions; and EPA's support for healthy mood management.

Nerve cells are the largest cells of the body. They rely on long "axon" stretches (up to four feet worth) with a high degree of membrane fluidity, which is necessary for the axons to generate, transmit, and integrate their electrical and chemical communications over significant distances. Adequate membrane fluidity hinges on having high DHA and other omega-3 content. Epidemiologic studies indicate that sufficiency of DHA and other omega-3s in the brain is necessary for the normal range of cognitive, mood and behavioral functions.

In the eye, the retinal photoreceptor cells also rely heavily on DHA and other omega-3s. DHA is more closely linked to good vision than is EPA, and dietary sufficiency of DHA in early life is linked to proper vision development as well as relative cognitive aptitude. DHA and EPA make up a substantial proportion of the fatty acids in healthy human breast milk.

Mood and behavior are also closely linked to DHA and EPA status. In children, better omega-3 status predicts better behavioral and learning patterns. Double-blind trials and other clinical experience demonstrate that children can markedly benefit from supplementation with DHA and EPA. A 2006 meta-analysis by the American Psychiatric Association found statistically significant benefit from DHA and EPA for adults as well.

Numerous epidemiologic studies, clinical trials, and other studies show that the crucial contributions of omega-3s for brain health begin well before birth and continue through childhood and adolescence into middle age and late life. For their significance to intelligence, healthy mood management and appropriate behavior, the brain benefits of DHA and the other omega-3s are emerging with an importance that parallels their well-established circulation benefits.

Benefits for the Joints and Other Tissues

DHA and EPA support healthy joint flexibility and overall performance, especially when supplemented in gram quantities daily. A 2007 meta-analysis of 17 randomized, controlled trials found that DHA and EPA significantly supported joint comfort and motility.

Though their benefits for some tissues have been studied more than others, supplementation with DHA and EPA very likely benefit all the tissues of the body. Proven benefits for other organ systems include:

• DHA plus EPA can support gastrointestinal lining, as shown in clinical trials. Omega-3 eicosanoids and docosanoids support a balanced immune response in the gut.
• Gastrointestinal: DHA and EPA support healthy cell replacement, perhaps via regulatory effects on genes linked to cell cycle control.
• Other: wide-ranging clinical benefits are linked to DHA and EPA influences on cell signaling and gene expression in many different cell types.

Dietary intakes of DHA and EPA currently are grossly insufficient in the typical Western diet. They are virtually absent from food plants, and severely lacking in the meat produced from farm animals raised in feedlots. This overall dietary lack contributes to measurable imbalances in the cell membrane fatty acid ratios, affecting the membrane fluidity that is so crucial to healthy metabolic functions. Individuals seeking optimal health are well advised to supplement their daily diet with DHA plus EPA.

It is not easy to construct a natural diet that is adequate in DHA plus EPA. Wild-caught cold-water fish are a viable source but are relatively expensive and often polluted with mercury and/or other toxic residues. Obtaining dietary supplements from reputable suppliers is the best way to ensure a clean, potent, and affordable daily supply. VESIsorb CoQ10 Plus Omega-3 combines these three functionally complementary cell membrane nutrients into one convenient to take, affordable and highly bioavailable preparation.

In addition to the dramatic improvement of CoQ10 absorption by VESIsorb, data from a preliminary human study suggests that VESIsorb also enhances DHA and EPA absorption. The combination of CoQ10, DHA and EPA into one supplement with VESIsorb delivery improves their likelihood for universally improving cell membrane efficiency and in turn for upgrading all the tissues and organs.

Cell membranes are the key to the most fundamental life processes, which in turn translate into the body's overall functional readiness and support optimal health. With CoQ10, DHA and EPA having complementary membrane functions, and considering that having sufficient status for these nutrients can have such wide-ranging positive effects, VESIsorb CoQ10 Plus Omega-3 offers great promise for promoting health and wellbeing at any age.

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