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Doctor's Best Sytrinol is a formula derived from citrus and palm fruit extracts. Doctor's Best Sytrinol is a combination of citrus flavonoids and palm-sourced tocotrienols that can exert potent antioxidant effects. Sytrinol may have its major effect in the liver by acting there to balance the production of cholesterol. Research shows that it may be beneficial in helping to maintain normal cholesterol levels in healthy people.

  • Science-based nutrition
  • Dietary supplement
  • Helps maintain normal cholesterol levels in healthy individuals

Sytrinol is a patented formula that combines citrus flavonoids with palm-sourced tocotrienols to promote potent antioxidant effects. The polymethoxylated flavones (PMFs) are a group of compounds that are derived from the peels of citrus fruits. PMFs are the predominant flavonoids found in Sytrinol, the two most prevalent being tangeretin and nobiletin. These compounds, on their own or in combination with other nutrients, have the ability to affect the metabolism of lipids.

Tocotrienols, the second major component of Sytrinol, are fat-soluble and naturally occurring "vitamers" of vitamin E (structurally similar to the tocopherols, but with more potent antioxidant power). They neutralize free radicals, thereby supporting maintenance of cardiovascular health.

Helps Maintain Normal Cholesterol Levels in Healthy Individuals

Research into the way PMFs modulate the production of lipids has revealed potential mechanisms of action. An in vitro experiment showed that tangeretin could modulate the production of triglycerides on an enzymatic level. Triglycerides are an important component of the body's lipid profile, and play a role in human health. Microsomal triglyceride transfer protein (MTP) and diacylglycerol acyltransferase (DGAT) are two components of triglyceride synthesis and transport within the cells. Tangeretin displayed inhibitory effects on MTP and suppressed the activity of DGAT, thereby influencing triglyceride metabolism. A subsequent in vitro study looked at the effects of nobiletin, the second major PMF present in Sytrinola. The results showed nobiletin to possess important free radical scavenging effects in the bloodstream.

A recent trial was conducted in hamsters to measure the effectiveness of a combination of tangeretin and nobiletin on serum cholesterol levels. This controlled trial investigated the effect of including these PMFs into the diet for 5 weeks. The control group received a normal, standardized diet free of PMFs. At the end of the experimental period, blood parameters indicated that the animals fed the tangeretin/nobiletin combination showed significantly favorable results for a number of lipid parameters. This research highlights the ability of these PMFs to have beneficial effects on the maintenance of cardiovascular health.

A number of studies have highlighted the cardiovascular health benefits of tocotrienols. Animal studies have shown important serum lipid modulating functions of various tocotrienols. Additional in vitro and animal research has documented the far-reaching benefits of tocotrienols on a number of cardiovascular markers. More importantly, human trials with tocotrienols have also shown positive results. Tocotrienol-rich palm oil or rice bran oil were used in these studies, and both showed significant effects on blood lipid levels. The various mechanisms of action of tocotrienols make them an ideal choice for promoting heart health.

Sytrinol combines the benefits of PMFs and tocotrienols in one convenient formula to promote cardiovascular health. Two initial small clinical trials and a double-blind study have shown that this combination supports maintenance of healthy cholesterol levels already in the normal range.

About Doctor's Best

Doctor's Best produces products with the highest quality raw materials available on the market. They have direct control over and are an integral part of every aspect of product production, from formulation and raw material sourcing to finished product manufacturing. We directly purchase all active ingredients used in our products and use only the highest quality ingredients.

Every product is thoroughly researched and backed by the latest scientific studies conducted in the field. The formulations reflect the amounts of ingredients shown to be beneficial based on the results of scientific investigations. Doctor's Best uses patented, trademarked ingredients backed by scientific studies and clinical research. They never use insignificant quantities to enhance the label.

Doctor's Best directly purchases only the highest grade raw materials from proven and reputable suppliers to be put into product formulations. All raw material suppliers go through their stringent vendor qualification process, which includes a multi-step investigation including all aspects of the production and handling procedures, to insure the highest level of quality is reached.

* [1] Note: Unless otherwise noted, this product has not been evaluated by the Food and Drug Administration. Our natural products are not intended to diagnose, treat, cure, or prevent any disease.