In Germany, doctors are recommending a natural extract from the herb butterbur (Petasites hybridus) to those who suffer from regular episodes of head cavity discomfort. In clinical trials in both Germany and the United States, butterbur reduced the incidence of head cavity discomforts by up to 61%. Butterbur's principal active constituent, petasin, reduces smooth muscle spasms and helps relax the constriction of cerebral blood vessels. Butterbur's ability to relax constricted arteries and smooth muscle may help control head cavity discomfort.
Life Extension's Migra-Eeze contains butterbur root extract standardized to provide 22.5 mg of petasins with each daily dose of two softgels. Riboflavin (vitamin B2) and ginger are included based on the ability of these nutrients to exert functional changes that may also guard against head cavity discomforts.