Pure Guild Moisturizing Treatment for Ultra-Dry Skin sets the new benchmark for molecular purity in topical treatments. Active ingredients in Pure Guild Moisturizing Treatment for Ultra-Dry Skin maintain their molecular integrity and full spectrum of biological activities because no solvents are used and no heat is applied to extract them. While common moisturizers dissipate quickly, Pure Guild Moisturizing Treatment for Ultra-Dry Skin strengthens and rebuilds the barrier function of the stratum corneum to retain innate moisture and resist environmental assault. Pure Guild Moisturizing Treatment for Ultra-Dry Skin achieves such intense moisturization because its active ingredient, Pichia anomala extract, stimulates lamellar-lipid transport, synthesis, and maturation within the epidermis.
- Pichia anomala recruits exogenous lipids into the keratinocytes, as demonstrated by a 33 percent increase in fatty-acid transport proteins.
- Inside skin cells, the extract stimulates lipid synthesis, measured as a 25 percent increase in the expression of lamellar-body proteins.
- For optimum integrity, the extract stimulates formation of lipid lamellae to seal intercellular spaces, as indicated by a 38 percent boost in key enzyme activity.
Reinforcing the barrier function at the cellular level means Pure Guild Moisturizing Treatment for Ultra-Dry Skin truly controls transepidermal water loss to retain natural moisture, so skin looks and feels young and healthy.
Pristine Mechanical Extraction
Pure Guild employs only gentle mechanical compression over time to render highly effective compounds from potent raw materials. Although costly, this process yields a superior molecule, while other organic brands use chemical solvents like hexane or ether, which adulterate the final product, and heat distillation, which inhibits therapeutic properties.
Super-premium Pure Guild cosmeceuticals contain no sodium lauryl sulfate or other detergents. They are strictly hypoallergenic, non-irritating, and never tested on animals.
Replenishing the Lipids for Skin Moisture
A disruption in the lipid structure of the stratum corneum induces dynamic regeneration in the epidermis to ensure homeostasis of the skin s barrier function. That is why Pure Guild Moisturizing Treatment for Ultra-Dry Skin incorporates Pichia anomala extract, a novel active botanical that boosts the synthesis, transport, secretion, and maturation of epidermal lipids. P anomala extract encourages formation of a functional lipid cement by stimulating:
- Recruitment of exogenous lipids
- Transportation and secretion of precursor lipids via lamellar bodies
- Maturation of lipid precursors into functional lipids in the lamellar layers and the cornified envelope
A pure mannan fraction obtained from Pichia anomala is a high-technology active ingredient a result of advanced research on fermentation. It boosts the natural lipid replenishment system of the skin to reinforce the integrity of its barrier function.
Barrier Function Of The Epidermis
The stratum corneum is made of corneocytes, which are keratinocytes cemented together by lamellar-lipid membranes. These lipids play a fundamental role in the structure and function of the epidermis, forming a barrier.
Their composition 50 percent ceramides, 25 percent cholesterol, and 15 percent long-chain free fatty acids and their arrangement as lipid bilayers in the spaces between the corneocytes determine the characteristics of the barrier.
The process of synthesis, transportation, secretion, and maturation of epidermal lipids ensures the homeostasis of the barrier function. The production of lamellar bodies, which release their contents into the intercellular spaces, continuously regenerates the lipid cement of the skin.
Epidermal lipid flow has several steps. First, lipids are synthesized by skin cells in the form of polar precursors glucosylceramides, cholesterol, and phospholipids from metabolic intermediates and fatty acids. These fatty acids may come from extra-cutaneous sites and be internalized by keratinocytes via specialized membrane transporters such as fatty-acid-transporter proteins (FATP).
The lipid precursors are generated in quantity and stored in organelles known as lamellar bodies, formed from the Golgi apparatuses. Lamellar bodies appear in the upper spiny layer, increasing volume and size in the granular layer. Inclusion of lipids within the lamellar bodies is ensured by ABCA12 proteins on their membranes. Lamellar bodies also contain lipases for lipid maturation, proteases and protease inhibitors for regulating desquamation, structural components for the corneal envelope, and anti-microbial peptides.
Lamellar bodies fuse with plasma membranes in the terminal differentiation phase and secrete their contents into the intercellular spaces at the junction of the stratum granulosum and the stratum corneum. Lipid precursors undergo modification by the enzymes -glucocerebrosidase, phospholipase, and sphingomyelinase, released at the same time.
Modification of the polarity and structure of the precursors results in the formation of lamellar membranes, the composition and arrangement of which determine the characteristics of the barrier function.
Omega-hydroxyceramides are bound to the envelopes of corneocytes, anchoring them to the lamellar membranes.
The essential function of the stratum corneum barrier has been known for years. Any quantitative or qualitative anomaly in its lipids leads to an increase of transepidermal water loss, a reliable marker. Many active ingredients have been proposed in recent years to encourage synthesis of new epidermal lipids to restructure the skin barrier.