SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body that is excellent for muscle pain, fibromyalgia, joint pain, rheumatoid arthritis, depression and liver disease. It is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways: Methylation (contributing methyl groups to activate certain molecules) The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals) In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency.
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