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Item #26444
Vitamin C by Doctor's Best
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Vitamin C
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Doctor's Best Best Vitamin C featuring Quali-C provides a brand of ascorbic acid manufactured in Scotland prized for its quality and reliability. Ascorbic acid is invaluable to the body for its role as an electron donor, supporting numerous metabolic enzymes in addition to enhancing the body’s total antioxidant potential. Essential for the synthesis of collagen, carnitine, and certain neurotransmitters, ascorbic acid can also aid in iron absorption. Research suggests that this vitamin supports many additional areas of health, including the cardiovascular and immune systems.

  • Science-based nutrition
  • Dietary supplement
  • Helps neutralize oxidative stress
  • Supports optimal immune function

Vitamin C is essential to the biosynthesis of the metabolic facilitator L-carnitine, the neurotransmitter norepinephrine, and the main connective tissue in the body, collagen. While these functions are obviously critical for our health, this vitamin is most widely revered for its role as a reducing agent (an electron donor), serving as a co-factor for hydroxylases (enzymes) in addition to enhancing the body’s total antioxidant potential. As a reducing agent, ascorbate also can aid in the absorption of dietary nonheme iron, helping those who need more iron from their daily intake.

Vitamin C is a key compound in the body’s “antioxidant network,” a chain of synergistic, inextricability linked, well-studied antioxidants that includes glutathione (GSH) and vitamin E. When vitamin E uses its antioxidant function in neutralizing free radicals, it also loses this antioxidant function. Vitamin C can change this status; it can regenerate vitamin E back to its native form, and is thought to “spare” glutathione in the body as well. Importantly, when ascorbate donates an electron and becomes itself oxidized, or “consumed,” the ascorbate radical is relatively harmless. In a double-blind, placebo-controlled study in which blood GSH was measured in healthy subjects at several stages, 500 mg of vitamin C taken daily for 2 weeks significantly raised erythrocyte (red blood cell) glutathione levels. The researchers concluded that vitamin C supplementation at that level can benefit the overall antioxidant capacity of the blood. In another study of similar design, 1000 mg of vitamin C taken daily for 4 weeks bolstered vitamin E and glutathione content in erythrocyte cell membranes, compared with placebo.

The highest concentrations of vitamin C in the body are found in the central nervous system (in neurons of the brain & spinal cord) and the adrenal glands. Although the presence of ascorbate in neurons is in part explained by its neuromodulatory enzyme activity, its high concentration suggests that vitamin C is so greatly retained by neurons in order to address the higher rates of oxidative metabolism experienced by the brain. This has led to the conclusion that under normal conditions, vitamin C helps safeguard the integrity of neurons (and therefore the brain), largely through neutralization of the free radicals of reactive oxygen species (ROS). Low levels of blood vitamin C and the resulting accumulation of ROS are thought to be detrimental—especially to aging populations.

Supports the Cardiovascular and Immune Systems

Most prospective studies assessing vitamin C intake in large numbers of people who are followed over time indicate that the highest intakes of vitamin C are associated with enhanced cardiovascular benefits. In addition, some large studies of healthy individuals who take vitamin C supplements suggest that supplementation supports healthy heart function. The Nurses’ Health Study of more than 85,000 women followed for over 16 years found vitamin C intakes of more than 359 mg per day from diet plus supplements or from supplements alone were associated with a more favorable cardiovascular health status. In a recent review of studies in which more than 290,000 healthy adults were followed for an average of 10 years, those who took more than 700 mg per day of supplemental vitamin C had a substantially better cardiovascular profile than those who did not take vitamin C supplements.

Oxidative stress is a central component of cardiovascular health, and vitamin C acts vigorously to counteract multiple avenues of oxidation that detract from cardiovascular health. Nitric oxide (NO) produced by endothelial cells (lining blood vessel walls) helps to maintain cardiovascular homeostasis and to safeguard blood vessels. Ascorbate helps to protect the normal NO biosynthesis pathway, which is easily disrupted by ROS. High levels of certain proteins in the blood serve as indicators of disruptions to both cardiovascular and immune system health. In a study of 3,258 healthy men, levels of vitamin C in the blood have been found to be inversely associated with these protein markers of unbalanced immune activation.

In a study examining the blood of 240 healthy subjects, the concentration of glutathione and ascorbate was measured in lymphocytes. Interestingly, the vitamin C levels of the lymphocytes varied significantly depending on the season (ascorbate levels were lower in the winter), confirming earlier research in which investigators had reported fluctuations in blood vitamin C levels with the seasons. The researchers propose that vitamin C supplementation will not only increase levels of ascorbate in lymphocytes, but GSH levels as well. Although not a controlled clinical trial, the results here are one more piece of the immune system puzzle, and they also hint at what time of year vitamin C supplementation may be most beneficial.

About Doctor's Best

Doctor's Best produces products with the highest quality raw materials available on the market. They have direct control over and are an integral part of every aspect of product production, from formulation and raw material sourcing to finished product manufacturing. We directly purchase all active ingredients used in our products and use only the highest quality ingredients.

Every product is thoroughly researched and backed by the latest scientific studies conducted in the field. The formulations reflect the amounts of ingredients shown to be beneficial based on the results of scientific investigations. Doctor's Best uses patented, trademarked ingredients backed by scientific studies and clinical research. They never use insignificant quantities to enhance the label.

Doctor's Best directly purchases only the highest grade raw materials from proven and reputable suppliers to be put into product formulations. All raw material suppliers go through their stringent vendor qualification process, which includes a multi-step investigation including all aspects of the production and handling procedures, to insure the highest level of quality is reached.

* [1] Note: Unless otherwise noted, products on our web site have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease.
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